Preferred Label : HM2/MMAE Antibody-Drug Conjugate ALT-P7;
NCIt synonyms : HM2-MMAE; HM2/MMAE ADC ALT-P7; ALT-P7; ADC ALT-P7;
NCIt definition : An antibody-drug conjugate (ADC) composed of the trastuzumab biobetter HM2 conjugated,
in a site-specific manner, to monomethyl auristatin E (MMAE), an auristatin derivative
and potent microtubule disrupting agent, with potential antineoplastic activity. Upon
administration of ALT-P7, the antibody moiety targets and binds to human epidermal
growth factor receptor 2 (HER2) on tumor cells. Upon antibody/antigen binding and
internalization, the MMAE moiety is released, binds to tubulin and inhibits its polymerization,
which results in G2/M phase arrest and apoptosis. HER2 is a receptor tyrosine kinase
(RTK) that is overexpressed by many cancer cell types.;
Molecule name : HER2ALT-P7;
NCI Metathesaurus CUI : CL554360;
Origin ID : C153102;
UMLS CUI : C4727022;
Semantic type(s)
- concept_is_in_subset
