Preferred Label : TetMYB DNA Vaccine;
NCIt synonyms : TetMYB; DNA Vaccine TetMYB; TetMYB Vaccine; DNA-based TetMYB Vaccine;
NCIt definition : A therapeutic engineered DNA vaccine composed of DNA sequences encoding for one or
more tetanus toxoid peptides and the oncoprotein MYB, with potential immunostimulatory
and antineoplastic activities. Upon intradermal administration, TetMYB is taken up
and processed by dendritic cells (DCs), which present the processed antigen to the
immune system. This activates cytotoxic T-lymphocytes (CTLs) and causes a CTL-mediated
immune response against MYB-expressing tumor cells. MYB, an oncoprotein and transcription
factor, is overexpressed in a variety of cancer types and is essential for tumor cell
growth, inhibition of differentiation, and protection from apoptosis. Its expression
is correlated with lower T-cell infiltration and poorer prognosis. As MYB is only
weakly immunogenic, the tetanus toxoid peptides enhance the T-cell mediated immune
responses against the MYB-expressing tumor cells.;
NCI Metathesaurus CUI : CL554353;
Origin ID : C153094;
UMLS CUI : C4727017;
Semantic type(s)
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
