Bezlotoxumab - CISMeF

Preferred Label : Bezlotoxumab;

NCIt definition : A human monoclonal antibody directed against Clostridium difficile Toxin B (TcdB), with anti-toxin activity. Upon intravenous infusion, the two Fab regions of bezlotoxumab bind to two distinct epitopes within the N-terminal half of the TcdB combined repetitive oligopeptide (CROP) domain, blocking the carbohydrate binding pockets of the toxin and preventing binding of the toxin to target host cells. TcdB is one of two exotoxins responsible for the symptoms of Clostridium difficile infections.;

UNII : 4H5YMK1H2E;

CAS number : 1246264-45-8;

Drug name : Zinplava;

Molecule name : MK-6072; MK 6072;

NCI Metathesaurus CUI : CL592045;

Details

Origin ID

C153084;

UMLS CUI

C4291320;

Currated CISMeF NLP mapping
- Bezlotoxumab [ICD-11 Extension code]
- Bezlotoxumab [SMS substance]
- Bezlotoxumab [Anticorps monoclonal]
- Bezlotoxumab (substance) [SNOMED CT concept]
- bezlotoxumab [MeSH Supplementary Concept]
- bezlotoxumab [MeSH concept]
See also inter- (CISMeF)
- Product containing bezlotoxumab (medicinal product) [SNOMED CT concept]
- Zinplava [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Bezlotoxumab (substance) [SNOMED CT concept]
- Product containing bezlotoxumab (medicinal product) [SNOMED CT concept]
- bezlotoxumab [ATC Code]
- bezlotoxumab [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- bezlotoxumab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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