Preferred Label : Antifungal Agent VL-2397;
NCIt related terms : VL-2397;
NCIt definition : A cyclic hexapeptide and natural compound isolated from the Malaysian leaf litter
fungus, Acremonium persicinium MF-347833, with potential antifungal activity against
various invasive fungal infections including invasive aspergillosis (IA). Upon administration,
VL-2397, by resembling the siderophore ferrichrome, is specifically taken up by fungal
cells through the membrane-bound transporter siderophore iron transporter 1 (Sit;
Sit1). Upon fungal cell entry, VL-2397 targets and binds to an as of yet undisclosed
intracellular site, thereby killing fungal cells. Since mammalian cells lack the Sit1
transporter, VL-2397 is not taken up by human cells.;
UNII : E39B3691TD;
CAS number : 1186200-57-6;
Molecule name : VL-2397; ASP 2397; ASP-2397; VL 2397;
NCI Metathesaurus CUI : CL554214;
Origin ID : C153067;
UMLS CUI : C5235269;
Semantic type(s)
- UMLS correspondences (same concept)
- VL-2397 [MeSH Supplementary Concept]
- concept_is_in_subset
