NCIt definition : A combination formulation of the antibiotic piperacillin and the beta-lactamase inhibitor
tazobactam with antibacterial activity. Piperacillin, a broad-spectrum, semisynthetic
penicillin, binds to and inactivates penicillin-binding proteins (PBP) located on
the inner membrane of the bacterial cell wall, thereby interfering with the cross-linking
of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. As
a result, the cell wall is weakened and the cell lyses. Tazobactam, a penicillanic
acid sulfone derivative, irreversibly binds to and inhibits bacterial beta-lactamase
at or near its active site, thereby preventing the destruction of the beta-lactamase
susceptible piperacillin by this bacterial enzyme.;
Alternative definition : NCI-GLOSS: A drug combination that is used to treat infection in people with cancer.
Piperacillin is a synthetic penicillin; tazobactam enhances the effectiveness of piperacillin.;
Currated CISMeF NLP mapping