Preferred Label : Futuximab;
NCIt synonyms : Immunoglobulin G1, Anti-(Human Epidermal Growth Factor Receptor Extracellular Domain
III) (Human-Mus Musculus Monoclonal 992 DS Heavy Chain), Disulfide with Human-Mus
Musculus Monoclonal 992 DS Light Chain, Dimer;
NCIt definition : A recombinant, chimeric monoclonal antibody directed against the epidermal growth
factor receptor (EGFR; ErbB1; HER1), with potential antineoplastic activity. Upon
administration, futuximab targets and binds to an epitope located in the extracellular
domain (ECD) of EGFR, which causes internalization and degradation of EGFR, including
the mutated EGFR variant III (EGFRvIII). This prevents EGFR-mediated signaling, thereby
inhibiting EGFR-dependent tumor cell proliferation. EGFR, a receptor tyrosine kinase,
is overexpressed on the cell surfaces of various solid tumor cell types.;
UNII : B37J680LX0;
CAS number : 1310460-85-5;
Molecule name : 992-DS; 992 DS;
NCI Metathesaurus CUI : CL554174;
Origin ID : C152971;
UMLS CUI : C4726993;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
