Vericiguat - CISMeF

Preferred Label : Vericiguat;

NCIt definition : An orally bioavailable stimulator of soluble guanylate cyclase (sGC), with vasodilating activity. Upon oral administration, vericiguat directly stimulates the catalytic activity of sGC and increases the formation of the intracellular second messenger cyclic guanosine monophosphate (cGMP), which is derived from guanosine triphosphate (GTP). This results in smooth muscle relaxation and vasodilation. sGC, a heme-containing cytoplasmic signaling enzyme, catalyzes the formation of cGMP from GTP in response to nitric oxide (NO) binding to heme. Vericiguat stimulates sGC independently of and synergistically with NO.;

UNII : LV66ADM269;

InChIKey : QZFHIXARHDBPBY-UHFFFAOYSA-N;

CAS number : 1350653-20-1;

Drug name : Verquvo;

Molecule name : BAY-1021189; MK-1242;

NCI Metathesaurus CUI : CL554066;

Détails

Origin ID

C152862;

UMLS CUI

C4078709;

Automatic exact mappings (from CISMeF team)
- vericiguat [ATC Code]
Currated CISMeF NLP mapping
- Vericiguat (substance) [SNOMED CT concept]
- vericiguat [MeSH Supplementary Concept]
- vericiguat [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing vericiguat (medicinal product) [SNOMED CT concept]
- Vericiguat (substance) [SNOMED CT concept]
- vericiguat [MeSH Supplementary Concept]
- vericiguat [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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