NCIt definition : An orally bioavailable stimulator of soluble guanylate cyclase (sGC), with vasodilating
activity. Upon oral administration, vericiguat directly stimulates the catalytic activity
of sGC and increases the formation of the intracellular second messenger cyclic guanosine
monophosphate (cGMP), which is derived from guanosine triphosphate (GTP). This results
in smooth muscle relaxation and vasodilation. sGC, a heme-containing cytoplasmic signaling
enzyme, catalyzes the formation of cGMP from GTP in response to nitric oxide (NO)
binding to heme. Vericiguat stimulates sGC independently of and synergistically with
NO.;