NCIt definition : An orally available inhibitor of the hepatitis C virus (HCV) non-structural protein
5A (NS5A) replication complex, with potential activity against HCV genotypes 1-6.
Although the exact mechanism of action of velpatasvir has not yet been completely
determined, upon oral administration and intracellular uptake, it appears to bind
to domain I of the NS5A protein. This inhibits the activity of the NS5A protein and
results in the disruption of the viral RNA replication complex, blockage of viral
HCV RNA production, and inhibition of viral replication. NS5A, a zinc-binding and
proline-rich hydrophilic phosphoprotein, plays a crucial role in HCV RNA replication.
HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae
family.;
Currated CISMeF NLP mapping