NCIt definition : An orally bioavailable calcitonin gene-related peptide (CGRP) receptor antagonist
that can be used in the acute treatment of migraines. Upon oral administration, ubrogepant
targets, binds to and blocks the activity of CGRP receptor. This prevents CGRP-mediated
signaling. By blocking the CGRP-mediated pathways, ubrogepant is able to ease migraine
symptoms, especially migraine headache pain. CGRP-mediated signaling plays a key role
in migraine pathogenesis.;