Preferred Label : Tridecactide;
NCIt synonyms : alpha1-13-Corticotropin; ACTH (1-13); alpha-Corticotropin 1-13; alpha-1-13-Corticotropin, HumanL-seryl-L-tyrosyl-L-seryl-L-methionyl-L-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valine;
NCIt definition : A synthetic 13-amino acid peptide analogue of the naturally occurring alpha-melanocyte
stimulating hormone (a-MSH) and derived from proteolytic cleavage of adrenocorticotropic
hormone (ACTH), with potential analgesia, antipyretic, antioxidative, cytoprotective,
anti-inflammatory and immunomodulating activities. Upon administration, tridecactide
mimics the action of a-MSH, binds to melanocortin receptors (MC-Rs) and stimulates
melanocytes to increase the production and release of melanin. In addition, tridecactide's
anti-inflammatory effects are through the activation of MC-Rs that are expressed in
a number of tissues, such as peripheral immune cells and hypothalamic neurons, and
affects various pathways regulating inflammatory responses. Specifically, tridecactide
inhibits the activation of nuclear factor-kappa B (NF-κB), inhibits the expression
of pro-inflammatory cytokines and adhesion molecule expression, prevents T-cell proliferation
and inflammatory cell migration. This agent may also suppress pro-inflammatory non-cytokine
regulators such as nitric oxide (NO), prostaglandin E (PGE), and reactive oxygen species
(ROS), and induces the expression of interleukin (IL) 10.;
UNII : T7PQK27HTI;
CAS number : 22006-64-0;
Molecule name : EK-12;
NCI Metathesaurus CUI : CL553944;
Origin ID : C152740;
UMLS CUI : C4726910;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
