Preferred Label : Technetium Tc-99M Trofolastat Chloride;
NCIt synonyms : Technetium (99mTc) Trofolastat Chloride;
NCIt definition : The chloride salt form of a radioconjugate composed of an urea-based human prostate-specific
membrane antigen (PSMA)-targeting ligand, conjugated to the gamma-emitting radioisotope
technetium Tc 99m, with potential use as a tracer for PSMA-expressing tumors using
single photon emission computed tomography/computed tomography (SPECT/CT). Upon intravenous
administration of the technetium Tc 99m trofolastat, the trofolastat moiety targets
and binds to PSMA-expressing tumor cells. Upon internalization, PSMA-expressing tumor
cells can be detected during SPECT/CT imaging. PSMA, a tumor-associated antigen and
type II transmembrane protein, is expressed on the membrane of prostatic epithelial
cells and overexpressed on prostate tumor cells.;
UNII : 45WAL7ZXQT;
InChIKey : HDYYYVRIHIIBCU-LCERUKBVSA-J;
CAS number : 1333117-95-5;
NCI Metathesaurus CUI : CL553864;
Origin ID : C152532;
UMLS CUI : C4726819;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
