NCIt definition : A 5-hydroxytryptamine-3 (5-HT3) receptor antagonist with antiemetic activity. RG 12915
binds to and antagonizes the action of serotonin on the 5-HT-3 receptor located on
vagal afferents in the chemoreceptor trigger zone (CTZ), resulting in suppression
of chemotherapy-induced nausea and vomiting.;