Preferred Label : Sirtratumab Vedotin;
NCIt synonyms : Anti-SLITRK6 Antibody-drug Conjugate AGS15E; Anti-SLITRK6 ADC AGS15E; Anti-SLITRK6 Monoclonal Antibody-MMAE Conjugate AGS15E;
NCIt definition : An antibody-drug conjugate (ADC) composed of sirtratumab, a monoclonal antibody directed
against SLIT and NTRK-like protein 6 (SLITRK6), covalently linked to the cytotoxic
agent monomethyl auristatin E (MMAE), an auristatin derivative and a potent inhibitor
of microtubule polymerization, with potential antineoplastic activity. Upon intravenous
administration, the monoclonal antibody moiety of sirtratumab vedotin binds to SLITRK6
expressed on tumor cells, which facilitates both the internalization of the ADC and
the intracellular delivery of MMAE. Upon cleavage, MMAE binds to tubulin and inhibits
its polymerization, which results in G2/M phase arrest and tumor cell apoptosis. SLITRK6,
a member of the Slitrk family of leucine-rich repeat (LRR) neuronal transmembrane
proteins, is minimally expressed in normal tissue but overexpressed in a variety of
cancers, including bladder cancer, some forms of lung cancer, breast cancer and glioblastoma.;
UNII : E58B6OP5QG;
CAS number : 1824663-83-3;
Molecule name : AGS-15E; ASG-15ME;
NCI Metathesaurus CUI : CL553574;
Origin ID : C152370;
UMLS CUI : C4726755;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
