Secukinumab - CISMeF

Preferred Label : Secukinumab;

NCIt definition : A recombinant human immunoglobulin G1 (IgG1) monoclonal antibody against the pro-inflammatory cytokine interleukin 17A (IL-17A; IL-17), with potential anti-inflammatory activity. Upon subcutaneous administration, secukinumab selectively targets and binds to IL-17A, thereby neutralizing the IL-17A protein. This prevents binding of IL-17A to the IL-17 receptor (IL-17R), and inhibits IL-17A/IL-17R-mediated signaling and inflammation mediated by this pathway. IL-17A is mainly produced by inflammatory T helper 17 cells (Th17), and certain lymphocytes. IL-17A production is upregulated in many immune-mediated inflammatory diseases and plays a key role in the development of inflammation and the immune response.;

UNII : DLG4EML025;

CAS number : 1229022-83-6;

Drug name : Cosentyx;

Molecule name : AIN457;

NCI Metathesaurus CUI : CL553647;

Details

Origin ID

C152315;

UMLS CUI

C3179547;

Currated CISMeF NLP mapping
- Secukinumab [ICD-11 Extension code]
- Secukinumab [SMS substance]
- Secukinumab [Anticorps monoclonal]
- Secukinumab (substance) [SNOMED CT concept]
- secukinumab [MeSH concept]
- secukinumab [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing secukinumab (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing secukinumab (medicinal product) [SNOMED CT concept]
- Secukinumab (substance) [SNOMED CT concept]
- secukinumab [ATC Code]
- secukinumab [MeSH concept]
- secukinumab [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- secukinumab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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