Sacubitril - CISMeF

Preferred Label : Sacubitril;

NCIt synonyms : (2R,4S)-5-(biphenyl-4-yl)-4-((3-carboxypropionyl)amino)-2-methylpentanoic acid ethyl ester;

NCIt definition : A neprilysn (NEP) inhibitor prodrug with natriuretic activity. Upon administration, sacubitril is metabolized by esterases to its active metabolite, sacubitrilat, which inhibits NEP, a neutral endopeptidase that cleaves natriuretic peptides such as atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and c-type natriuretic peptide (CNP), as well as certain vasoconstricting peptides including as angiotensin I and II, and endothelin-1. Additionally, sacubitrilat may inhibit NEP-mediated catabolism of certain peptide-based agents, thereby improving their in vivo stability and increasing tumor cell exposure.;

UNII : 17ERJ0MKGI;

InChIKey : PYNXFZCZUAOOQC-UTKZUKDTSA-N;

CAS number : 149709-62-6;

Molecule name : AHU-377; AHU 377;

NCI Metathesaurus CUI : CL553613;

Details

Origin ID

C152281;

UMLS CUI

C4033447;

Currated CISMeF NLP mapping
- Sacubitril [SMS substance]
- Sacubitril (substance) [SNOMED CT concept]
- [1,1'-biphenyl]-4-pentanoic acid, gamma-[(3-carboxy-1-oxopropyl)amino]-alpha-methyl-, alpha-ethyl ester, (alpha-r,gamma-s)- [Substance BNPC]
- sacubitril [MeSH concept]
- sacubitril [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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