NCIt definition : A humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting the p19 subunit
of human interleukin 23 (IL-23) cytokine, with anti-inflammatory activity. Upon administration,
risankizumab targets and binds to the p19 subunit of human IL-23, inhibiting the interaction
of IL-23 with the IL-23 receptor complex. This inhibits IL-23/IL-23 receptor-mediated
signaling and inhibits the release of pro-inflammatory cytokines and chemokines. IL-23
plays an important role in the development, maintenance and activation of Th17 cells,
which produce pro-inflammatory cytokines including IL-17A, IL-17F, and IL-22. It is
upregulated in various inflammatory and autoimmune diseases.;