" /> Riociguat - CISMeF





Preferred Label : Riociguat;

NCIt definition : An orally bioavailable stimulator of soluble guanylate cyclase (sGC), with vasodilating activity. Upon oral administration, riociguat directly stimulates the catalytic activity of sGC. In addition, riociguat stabilizes the binding of nitric oxide (NO) to sGC. Altogether this stimulates the NO-sGC-cyclic guanosine monophosphate (cGMP) pathway and increases the formation of the intracellular second messenger cGMP, which results in smooth muscle relaxation and vasodilation. sGC, a heme-containing cytoplasmic signaling enzyme, catalyzes the formation of cGMP from guanosine triphosphate (GTP) in response to NO binding to heme. Riociguat stimulates sGC independently of and synergistically with NO.;

UNII : RU3FE2Y4XI;

InChIKey : WXXSNCNJFUAIDG-UHFFFAOYSA-N;

CAS number : 625115-55-1;

Drug name : Adempas;

Molecule name : BAY-63-2521; BAY 63-2521;

NCI Metathesaurus CUI : CL553429;

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28/07/2025


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