Preferred Label : Razuprotafib;
NCIt definition : A small molecule inhibitor of vascular endothelial protein tyrosine phosphatase (VE-PTP),
with potential vasculature stabilizing activity. Upon administration, razuprotafib
targets, binds to and inhibits VE-PTP, which is a negative regulator of the endothelial
cell (EC)-specific receptor tyrosine kinase (RTK) Tie2. This restores Tie2 activation,
which may improve endothelial function and stabilize blood vessels. VE-PTP is upregulated
in stressed endothelium associated with a variety of diseases. Tie2 plays an important
role in endothelial function and vascular stability. A decrease in Tie2 activation
leads to vascular leakage and inflammation.;
UNII : 0WAX4UT396;
InChIKey : KWJDHELCGJFUHW-SFTDATJTSA-N;
CAS number : 1008510-37-9;
Molecule name : AKB-9778; AKB 9778;
NCI Metathesaurus CUI : CL553493;
Origin ID : C152161;
UMLS CUI : C4726664;
Semantic type(s)
- concept_is_in_subset
