NCIt definition : The succinate form of rabacfosadine, an acyclic nucleotide phosphonate prodrug and
polymerase inhibitor that can potentially be used for its antineoplastic activity
in the treatment of lymphoma in dogs. Upon administration, rabacfosadine is hydrolyzed
intracellularly to 9-(2-phosphonylmethoxyethyl)-N6-cyclopropyl-2, 6-diaminopurine
(cPrPMEDAP) and subsequently deaminated to 9-(2-phosphonylmethoxyethyl) guanine (PMEG)
and phosphorylated to PMEG diphosphate (PMEGpp). PMEGpp binds to and inhibits DNA
polymerases. This inhibits DNA synthesis, resulting in S phase arrest and induction
of apoptosis.;
Semantic type(s)