Voxelotor - CISMeF

Preferred Label : Voxelotor;

NCIt synonyms : Benzaldehyde, 2-Hydroxy-6-((2-(1-(1-methylethyl)-1H-pyrazol-5-yl)-3-pyridinyl)methoxy)-;

NCIt definition : An orally bioavailable modulator and stabilizer of sickle cell hemoglobin (HbS), with potential use in the treatment of sickle cell disease (SCD). Upon administration, voxelotor targets and covalently binds to the N-terminal valine of the alpha chain of HbS. This stabilizes HbS, thereby improving oxygen binding affinity. The binding of voxelotor to HbS prevents HbS polymerization, reduces sickling, decreases red blood cell (RBC) damage and increases the half-life of RBCs. This improves blood flow and decreases hemolytic anemia.;

UNII : 3ZO554A4Q8;

InChIKey : FWCVZAQENIZVMY-UHFFFAOYSA-N;

CAS number : 1446321-46-5;

Drug name : Oxbryta;

Molecule name : GBT-440; GBT 440; GTX 011; GTX-011;

NCI Metathesaurus CUI : CL553297;

Codes from synonyms : 29560;

Details

Origin ID

C152089;

UMLS CUI

C4723629;

Automatic exact mappings (from CISMeF team)
- voxelotor [ATC Code]
Currated CISMeF NLP mapping
- Voxelotor [SMS substance]
- Voxelotor (substance) [SNOMED CT concept]
- voxelotor [MeSH Supplementary Concept]
- voxelotor [MeSH concept]
See also inter- (CISMeF)
- Oxbryta [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing voxelotor (medicinal product) [SNOMED CT concept]
- Voxelotor (substance) [SNOMED CT concept]
- voxelotor [MeSH Supplementary Concept]
- voxelotor [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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