Preferred Label : Modotuximab;
NCIt synonyms : Zatuximab; Immunoglobulin G1, Anti-(human epidermal growth factor receptor extracellular domain
III) (human-mus musculus monoclonal 1024 DS heavy chain), Disulfide with human-mus
musculus monoclonal 1024 DS light chain, Dimer;
NCIt definition : A recombinant immunoglobulin G1 (IgG1) monoclonal antibody directed against the epidermal
growth factor receptor (EGFR), with potential antineoplastic activity. Upon administration,
modotuximab targets and binds to an epitope located in the extracellular domain (ECD)
of EGFR, which causes internalization and degradation of EGFR, including the mutated
EGFR variant III (EGFRvIII). This prevents EGFR-mediated signaling, thereby inhibiting
EGFR-dependent tumor cell proliferation. EGFR, a receptor tyrosine kinase, is often
overexpressed on the cell surfaces of various solid tumor cell types.;
UNII : 1W7BD1M08N;
CAS number : 1310460-86-6;
Molecule name : 1024 DS; 1024-DS;
NCI Metathesaurus CUI : CL553284;
Origin ID : C152075;
UMLS CUI : C4726629;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
