Preferred Label : Sizavaleucel;
NCIt synonyms : Donor-derived CD34 HPCs/CD3 T-cells MDR-101; Donor-derived CD34 Hematopoietic Stem and Progenitor Cells Plus CD3 T-cells MDR-101;
NCIt definition : A preparation of allogeneic, organ donor-derived CD34-positive hematopoietic stem
and progenitor cells (HPCs) and CD3-positive T-cells that can be used after organ
transplantation to potentially prevent organ rejection. Upon infusion of sizavaleucel
after organ transplantation, these cells mix and co-exist with the recipient's blood
and immune cells, thereby inducing hematologic mixed chimerism and enabling the recipient's
immune system to become immune tolerant to the donor cells. This increases acceptance
of the transplanted organ, decreases the risk of organ transplant rejection, increases
organ survival and may decrease the need for additional immunosuppressive agents.
Sizavaleucel is ex vivo processed in a specific and unique way which has yet to be
fully elucidated. Cell doses are dependent on the degree of human leukocyte antigen
(HLA)-match/HLA-mismatch between the recipient and donor.;
UNII : P4NC6C4ABZ;
Molecule name : MDR-101; MDR 101;
NCI Metathesaurus CUI : CL553191;
Origin ID : C151968;
UMLS CUI : C5667170;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
