Preferred Label : HPV16-E7-T512;
NCIt synonyms : HPV16-targeting TALEN T512;
NCIt definition : A transcription activator-like effector nucleases (TALEN)-edited plasmid targeting
human papillomavirus (HPV) type 16 (HPV16) epitope E7, with potential antineoplastic
activity. Upon administration of TALEN-edited HPV16 E7 T512, the TALEN targets and
binds to a specific site on genomic HPV16 E7, and cleaves the DNA sequences encoding
E7. This causes double-strand DNA (dsDNA) breaks within the viral DNA, which prevents
the transcription and translation of E7. Inhibition of E7 expression restores and
increases the expression of tumor suppressor genes, such as retinoblastoma 1 (RB1),
and promotes downstream signaling. Altogether, TALEN-based HPV editing increases cell
cycle arrest, induces apoptosis, reduces viral replication and load, eliminates HPV
and inhibits tumor cell proliferation of HPV-driven cancer cells. HPV16 E7 is an oncogene
that is vital to viral function and HPV infection, and promotes carcinogenesis.;
Molecule name : T512;
NCI Metathesaurus CUI : CL553186;
Origin ID : C151958;
UMLS CUI : C4726582;
Semantic type(s)
- concept_is_in_subset
