Preferred Label : HPV16-E6-T27;
NCIt synonyms : HPV16-targeting TALEN T27;
NCIt definition : A transcription activator-like effector nucleases (TALEN)-edited plasmid targeting
the human papillomavirus (HPV) type 16 (HPV16) epitope E6, with potential antineoplastic
activity. Upon administration of TALEN-edited HPV16 E6 T27, the TALEN targets and
binds to a specific site on genomic HPV16 E6 and cleaves the DNA sequences encoding
E6. This causes double-strand DNA (dsDNA) breaks within the viral DNA, which prevents
the transcription and translation of E6. Inhibition of E6 expression restores and
increases the expression of tumor suppressor genes, such as p53, and proapoptotic
protein BAK, and promotes downstream signaling. Altogether, TALEN-based HPV editing
increases apoptosis, reduces viral replication and viral load, eliminates HPV and
inhibits tumor cell proliferation of HPV-driven cancer cells. HPV16 E6 is an oncogene
vital to viral function and HPV infection, and promotes carcinogenesis.;
Molecule name : T27;
NCI Metathesaurus CUI : CL553184;
Origin ID : C151956;
UMLS CUI : C4726580;
Semantic type(s)
- concept_is_in_subset
