NCIt synonyms : CaSR Agonist SK 1403; Calcium-sensing Receptor Agonist SK 1403;
NCIt definition : The sodium hydrate form of upacicalcet, an agonist of calcium-sensing receptors (CaSR),
with potential use in the treatment of secondary hyperparathyroidism (SHPT). Upon
administration, upacicalcet targets and binds to CaSRs expressed on the membranes
of cells in the parathyroid glands, which suppresses osteoclast activity and reduces
the excessive secretion of parathyroid hormone (PTH). This prevents the excessive
PTH-mediated efflux of phosphorus and calcium from bone into the blood and normalizes
serum calcium and phosphorus levels. Upacicalcet may decrease the risk of bone fracture,
may lower depositions of phosphorus and calcium salts in non-bone tissues, may reduce
bone and joint pain and may slow the progression of other diseases related to increased
levels of PTH. CaSR controls calcium homeostasis and regulates the release of PTH.;
UNII : DH9LW5L96P;
Drug name : UPASITA;
Molecule name : SK1403; AJT-240; PLS-240; PLS 240;
Semantic type(s)