" /> Upacicalcet Sodium Hydrate - CISMeF





Preferred Label : Upacicalcet Sodium Hydrate;

NCIt synonyms : CaSR Agonist SK 1403; Calcium-sensing Receptor Agonist SK 1403;

NCIt definition : The sodium hydrate form of upacicalcet, an agonist of calcium-sensing receptors (CaSR), with potential use in the treatment of secondary hyperparathyroidism (SHPT). Upon administration, upacicalcet targets and binds to CaSRs expressed on the membranes of cells in the parathyroid glands, which suppresses osteoclast activity and reduces the excessive secretion of parathyroid hormone (PTH). This prevents the excessive PTH-mediated efflux of phosphorus and calcium from bone into the blood and normalizes serum calcium and phosphorus levels. Upacicalcet may decrease the risk of bone fracture, may lower depositions of phosphorus and calcium salts in non-bone tissues, may reduce bone and joint pain and may slow the progression of other diseases related to increased levels of PTH. CaSR controls calcium homeostasis and regulates the release of PTH.;

UNII : DH9LW5L96P;

Drug name : UPASITA;

Molecule name : SK1403; AJT-240; PLS-240; PLS 240;

NCI Metathesaurus CUI : CL553183;

Détails


Position du mot-clé dans l'(les) arborescence(s) : arborescence

Vous pouvez consulter :


Nous contacter.
28/07/2025


[Accueil] [Haut de page]

© CHU de Rouen. Toute utilisation partielle ou totale de ce document doit mentionner la source.