Trotabresib - CISMeF

Preferred Label : Trotabresib;

NCIt synonyms : BET Inhibitor CC-90010; 4-(2-(Cyclopropylmethoxy)-5-methylsulfonylphenyl)-2-methylisoquinolin-1-one;

NCIt definition : An orally bioavailable inhibitor of the Bromodomain and Extra-Terminal (BET) family of proteins, with potential antineoplastic activity. Upon oral administration, trotabresib preferentially binds to the second bromodomain (BD2) of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histones. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of proliferation in BET-overexpressing tumor cells. BET proteins (BRD2, BRD3, BRD4 and BRDT) are transcriptional regulators that contain two homologous bromodomains, the BD1 and BD2 domains. They play an important role during development and cellular growth.;

UNII : K424WH3WU0;

CAS number : 1706738-98-8;

Molecule name : CC-90010; CC 90010;

NCI Metathesaurus CUI : CL553179;

Details

Origin ID

C151951;

UMLS CUI

C5554547;

False automatic mappings
- Chiari malformation type II [OMIM Phenotype]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Bromodomain Testis-Specific Protein [NCIt concept]
- Bromodomain-Containing Protein 2 [NCIt concept]
- Bromodomain-Containing Protein 3 [NCIt concept]
- Bromodomain-Containing Protein 4 [NCIt concept]

Keyword's position in hierarchy(ies) :

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