Preferred Label : CD16/IL15/CD33 Trispecific Killer Cell Engager OXS-3550;
NCIt synonyms : CD16/IL-15/CD33 161533 Tri-Specific Killer Engagers; CD16/IL15/CD33 TriKE OXS-3550; 161533 TRIKE;
NCIt related terms : OXS-3550;
NCIt definition : A trispecific killer engager (TriKE) molecule containing an anti-cluster of differentiation
16 (CD16; FcgammaRIII) single-chain variable fragment (scFv) to engage natural killer
(NK) cells, an anti-CD33 scFv to engage myeloid cells and a human modified interleukin-15
(IL-15) linker, that links the two scFv, with potential immunomodulating and antineoplastic
activities against CD33-expressing tumor cells. Upon administration of the CD16/IL15/CD33
TriKE OXS-3550, the simultaneous binding to CD16 on NK cells and CD33 on tumor cells
will induce NK cell cytotoxicity specifically against CD33-expressing tumor cells.
The cytokine IL-15 linker promotes NK cell proliferation, activity, survival and expansion.
CD33 is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed
on myeloid leukemia cells.;
UNII : E5GE91Q5FX;
CAS number : 2094086-30-1;
Molecule name : 161533; OXS-3550; OXS 3550; OXIS3550;
NCI Metathesaurus CUI : CL553176;
Origin ID : C151948;
UMLS CUI : C5446326;
Semantic type(s)
- concept_is_in_subset
