Preferred Label : Topical Potassium Dobesilate;
NCIt definition : A topical formulation composed of an inhibitor of fibroblast growth factor (FGF),
with potential antineoplastic activity. Upon topical administration potassium dobesilate
selectively binds to and blocks the activity of FGF, interferes with the binding of
FGF to FGFR and prevents FGFR-mediated signaling. This inhibits angiogenesis and tumor
cell proliferation, and induces cell death in FGFR-overexpressing tumor cells. FGF
plays a key role in angiogenesis, tumor cell proliferation, survival and invasiveness,
and is upregulated in many tumor cell types.;
Molecule name : AM-001;
NCI Metathesaurus CUI : CL553174;
Origin ID : C151946;
UMLS CUI : C4726571;
Semantic type(s)
- concept_is_in_subset
