Preferred Label : Therapeutic Liver Cancer Peptide Vaccine IMA970A;
NCIt synonyms : HCC Vaccine IMA970A;
NCIt definition : An off-the-shelf hepatocellular cancer (HCC) multi-peptide-based therapeutic vaccine
composed of sixteen peptides derived from tumor-associated antigens (TAAs) expressed
by hepatic tumor cells, of which seven are restricted to human leukocyte antigen (HLA)-A2
(HLA-A*02), five to HLA-A*24 and four to HLA class II, with potential immunomodulating
and antineoplastic activities. Upon intradermal administration of the therapeutic
liver cancer peptide vaccine IMA970A, the liver-specific peptides in the vaccine activate
the immune system to exert both CD4 T-helper and CD8 cytotoxic T-lymphocyte (CTL)-mediated
immune responses against liver cancer cells.;
Molecule name : IMA970A;
NCI Metathesaurus CUI : CL553170;
Origin ID : C151942;
UMLS CUI : C4726568;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
