Preferred Label : Onilcamotide;
NCIt synonyms : RV001 Vaccine; RhoC Peptide Vaccine RV001V;
NCIt definition : A cancer vaccine composed of an immunogenic peptide derived from the Ras homolog family
member C (RhoC; Rho-related GTP-binding protein RhoC) that is emulsified in the immunoadjuvant
montanide ISA-51, with potential immunomodulating and antineoplastic activities. Upon
subcutaneous administration, onilcamotide may stimulate the host immune system to
mount a humoral and cytotoxic T-lymphocyte (CTL) response against tumor cells expressing
RhoC, which results in tumor cell lysis. RhoC, a tumor-associated antigen (TAA) that
is overexpressed in a variety of tumor cell types, is associated with increased metastatic
potential.;
UNII : UQE6KP7T0D;
CAS number : 1164096-85-8;
Molecule name : RV 001; RV001V; RV 001V;
NCI Metathesaurus CUI : CL553276;
Origin ID : C151937;
UMLS CUI : C5554546;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
