Preferred Label : Cinobufotalin;
NCIt synonyms : 5-Beta-bufa-20,22-dienolide, 14,15-beta-epoxy-3-beta,5,16-beta-trihydroxy-, 16-Acetate; 5b,20(22)-Bufadienolide-14,15b-epoxy-3b,5a,16b-triol 16-Acetate; CB; 14,15b-Epoxy-3b,5a,16b-trihydroxy-5b,20(22)-bufadienolide 16-Acetate;
NCIt definition : A bufadienolide isolated from toad venom and utilized in traditional Chinese medicine
(TCM) for its cardiotonic, diuretic and hemostatic effects, with potential cytotoxic
and antineoplastic activities. Upon administration and although the exact mechanism
of action(s) (MoAs) through which this agent exerts its effects have yet to be fully
discovered, cinobufotalin causes DNA fragmentation, decreases mitochondrial membrane
potential (MMP), increases intracellular calcium (Ca2 ) ion concentrations and reactive
oxygen species (ROS) production, upregulates Fas protein and activates cytochrome
C, various caspases, Bid and Bax. This causes cell cycle arrest, induces apoptosis
and inhibits tumor cell growth and survival. In addition, cinobufotalin inhibits the
activity of sphingosine kinase 1 (SphK1) and induces pro-apoptotic ceramide production,
which further promotes tumor cell apoptosis. Cinobufotalin also induces mitochondrial
protein cyclophilin D (Cyp-D)-dependent opening of the mitochondrial permeability
transition pore (mPTP), which may contribute to cinobufotalin-induced non-apoptotic
death of certain tumor cells.;
UNII : L0QBZ37386;
CAS number : 1108-68-5;
NCI Metathesaurus CUI : CL553268;
Origin ID : C151929;
UMLS CUI : C0526532;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
