Preferred Label : Efineptakin alfa;
NCIt synonyms : IL-7-hyFc; Il-7 Hybrid Fc; rhIL-7-hyFc; Glycosylated Recombinant Human Interleukin-7; Hyleukin-7 (TM);
NCIt related terms : NT-I7 Recombinant Human Interleukin-7-hyFc;
NCIt definition : A long-acting immunoglobulin (Ig) fusion protein composed of a recombinant form of
the endogenous human protein interleukin-7 (rhIL-7) and fused to a hybrid Fc (hyFc)
region of a human antibody, with hematopoietic and immunopotentiating activities.
Upon administration of efineptakin alfa, IL-7 stimulates the proliferation, differentiation,
trafficking and survival of a variety of T-cell subsets, including naive, central
memory (CM), effector memory (EM), terminally differentiated effector memory (TEMRA)
and natural killer (NK) T-cells, and enhances T-cell-mediated anti-tumor immune responses.
Compared to rhIL-7 alone, fusion to the hyFc region enhances the half-life of IL-7.
The hyFc region is composed of the hinge and N-terminal portion of heavy chain constant
(CH) region 2 (hinge-CH2) of human IgD, which is fused to the C-terminal region of
CH2 and the entire CH3 region of human IgG4.;
UNII : 3K3WC6MT6P;
CAS number : 2026634-47-7;
Molecule name : NT-I7; GX-I7; TJ-107; TJ 107;
NCI Metathesaurus CUI : CL553266;
Origin ID : C151927;
UMLS CUI : C5235406;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
