Roquinimex - CISMeF

Preferred Label : Roquinimex;

NCIt synonyms : N-Phenyl-N-methyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxamide; 1,2-Dihydro-4-hydroxy-N,1-dimethyl-2-oxo-3-quinolinecarboxanilide;

NCIt related terms : 1,2-Dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide;

NCIt definition : A quinoline-3-carboxamide with potential antineoplastic activity. Roquinimex inhibits endothelial cell proliferation, migration, and basement membrane invasion; reduces the secretion of the angiogenic factor tumor necrosis factor alpha by tumor-associated macrophages (TAMs); and inhibits angiogenesis. This agent is also an immune modulator that appears to alter cytokine profiles and enhance the activity of T cells, natural killer cells, and macrophages. (NCI04);

UNII : 372T2944C0;

InChIKey : SGOOQMRIPALTEL-UHFFFAOYSA-N;

CAS number : 84088-42-6;

Drug name : Linomide;

Molecule name : FCF 89; LS 2616;

Chemical formula : C18H16N2O3;

Codes from synonyms : 09087;

Details

Origin ID

C1519;

UMLS CUI

C0244748;

Automatic exact mappings (from CISMeF team)
- Roquinimex [ICD-11 Extension code]
Currated CISMeF NLP mapping
- roquinimex [MeSH concept]
- roquinimex [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- roquinimex [ATC Code]
- roquinimex [MeSH concept]
- roquinimex [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- roquinimex [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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