Preferred Label : Venlafaxine Hydrochloride Extended Release;
NCIt synonyms : Venlafaxine HCl ER;
NCIt definition : An extended-release (ER) formulation composed of the hydrochloride salt form of venlafaxine,
a synthetic phenethylamine bicyclic derivative and serotonin (5-hydroxytryptamine;
5-HT) and norepinephrine (NE) reuptake inhibitor (SNRI), with antidepressant and anti-anxiety
activities and with potential use in the treatment of neuropathic pain. Upon administration,
venlafaxine is released from the formulation in a controlled manner for an extended
period of time. Venlafaxine, and its main active metabolite, O-desmethylvenlafaxine
(ODV), selectively bind to the pre-synaptic 5-HT and NE transporters in the synaptic
cleft and inhibit the re-uptake of 5-HT and NE, and to a lesser extent dopamine, thereby
prolonging and potentiating the activities and signaling mediated by these neurotransmitters
in the central nervous system (CNS). This relieves depressive and anxious states.
Additionally, venlafaxine may exert analgesic effects through blockade of neuronal
NE reuptake and inhibition of nociceptive pathways, or through its potential to regulate
monoaminergic and opioidergic systems.;
Drug name : Effexor XR;
NCI Metathesaurus CUI : CL552620;
Origin ID : C150751;
UMLS CUI : C2918046;
Semantic type(s)
- concept_is_in_subset
