Preferred Label : MEK Inhibitor SHR 7390;
NCIt synonyms : MAP2K Inhibitor SHR 7390; MAPK Kinase Inhibitor SHR 7390; MEKi SHR 7390;
NCIt definition : An orally available small molecule inhibitor of mitogen-activated protein kinase kinase
(MAP2K; MAPK/ERK kinase; MEK), with potential antineoplastic activity. Upon administration,
MEK inhibitor SHR 7390 selectively binds to and inhibits the activity of MEK. This
prevents the activation of MEK-dependent effector proteins, which results in the inhibition
of growth factor-mediated cell signaling and tumor cell proliferation. MEK, a dual-specificity
threonine/tyrosine kinase family that plays a key role in the activation of the RAS/RAF/MEK/ERK
signaling pathway, is frequently upregulated in a variety of tumor cell types.;
Molecule name : SHR 7390; SHR-7390;
NCI Metathesaurus CUI : CL552486;
Origin ID : C150680;
UMLS CUI : C4725919;
Semantic type(s)
- concept_is_in_subset
