Preferred Label : Anti-CD26 Monoclonal Antibody YS110;
NCIt definition : A humanized, immunoglobulin G1 (IgG1) monoclonal antibody directed against the extracellular
domain of dipeptidyl peptidase 4 (CD26; DPP4; DPP IV), with potential antineoplastic
activity. Upon administration of anti-CD26 monoclonal antibody YS110, this antibody
targets and binds to CD26 expressed on tumor cells. This inhibits CD26 activity and
causes internalization of CD26-YS110. This leads to cell cycle arrest, lysis and inhibition
of growth in CD26-positive tumor cells. YS110 also induces antibody-dependent cellular
cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) against CD26-expressing
tumor cells. CD26, a 110-kDa, type II transmembrane glycoprotein, is overexpressed
in a variety of cancer cell types while absent in normal, healthy cells and plays
a key role in tumor cell growth, migration, invasion and survival. It also plays a
major role in the regulation of T-cell activity.;
Molecule name : YS110;
NCI Metathesaurus CUI : CL552568;
Origin ID : C150677;
UMLS CUI : C4725916;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
