Preferred Label : Serclutamab Talirine;
NCIt synonyms : ADC ABBV-321; Anti-EGFR/PBD ADC ABBV-321;
NCIt definition : A antibody drug conjugate (ADC) consisting of serclutamab, an affinity-matured humanized
monoclonal antibody directed against the epidermal growth factor receptor (EGFR) conjugated
to a talirine, a cytotoxic, DNA minor groove crosslinking agent and pyrrolobenzodiazepine
(PBD) dimer, with potential antineoplastic activity. Upon intravenous administration
of serclutamab talirine, the serclutamab moiety targets and binds to EGFR on tumor
cell surfaces. Following receptor internalization and lysosome-mediated cleavage,
talirine is released. In turn, the imine groups of the PBD moiety bind to the N2 positions
of guanines on opposite strands of DNA. This induces DNA strand breaks, inhibits DNA
replication, leads to G2/M cell cycle arrest, induces cell death, and inhibits the
proliferation of EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase
(RTK) that is overexpressed by a variety of cancers, plays a key role in tumor cell
proliferation and survival.;
UNII : 7W0O278T12;
CAS number : 2140174-56-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2140174-56-5
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G-SRS /a ;
Molecule name : ABBV-321; ABBV 321;
NCI Metathesaurus CUI : CL552328;
Origin ID : C150590;
UMLS CUI : C5418247;
Semantic type(s)
- concept_is_in_subset
