IgM Monoclonal Gammopathy of Undetermined Significance

Preferred Label : IgM Monoclonal Gammopathy of Undetermined Significance;

NCIt synonyms : IgM MGUS;

NCIt definition : Monoclonal gammopathy of undetermined significance defined by a serum IgM paraprotein concentration less than 30g/L; bone marrow lymphoplasmacytic infiltration of less than 10%; and no evidence of anemia, constitutional symptoms, hyperviscocity, lymphadenopathy, hepatosplenomegaly, or other end-organ damage that can be attributed to the underlying lymphoproliferative disorder. It is a precursor condition that may progress to lymphoplasmacytic lymphoma/ Waldenstrom macroglobulinemia, other B-cell neoplasms, or primary amyloidosis. Progression to plasma cell myeloma occurs rarely, if at all. (WHO 2017);

Neoplastic status : Undetermined;

NCI Metathesaurus CUI : CL552352;

Details

Origin ID

C150566;

UMLS CUI

C0563312;

Automatic exact mappings (from CISMeF team)
- IgM monoclonal gammopathy of undetermined significance [ICD-11 Extension code]
- Immunoglobulin M monoclonal gammopathy of undetermined significance (morphologic abnormality) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Immunoglobulin M monoclonal gammopathy of uncertain significance (disorder) [SNOMED CT concept]
Disease excludes abnormal cell
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
Has associated anatomic sites
- Hematopoietic System [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Immunoglobulin M monoclonal gammopathy of uncertain significance (disorder) [SNOMED CT concept]
- Immunoglobulin M monoclonal gammopathy of undetermined significance (morphologic abnormality) [SNOMED CT concept]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
disease_excludes_finding
- Aberrant Clonal Plasma Cell Population [NCIt concept]
- Constitutional Symptom [NCIt concept]
- Hepatosplenomegaly [NCIt concept]
- Lymphadenopathy [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
disease_has_finding
- Bone Marrow Lymphoplasmacytic Infiltration of Less than 10% [NCIt concept]
- Borderline Lesion [NCIt concept]
- Monoclonal Gammopathy [NCIt concept]
- Serum IgM Monoclonal Gammopathy of Less than 30g/L [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Mature B-Lymphocyte [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients