Preferred Label : Allogeneic Most Closely HLA-matched Adenovirus-specific Cytotoxic T Lymphocytes;
NCIt synonyms : Most Closely HLA Matched Third-Party Donor Adenovirus Specific T Cells; Most Closely HLA Matched Third-Party Donor Adenovirus Specific CTLs;
NCIt definition : A population of off the shelf, closely human leukocyte antigen (HLA)-matched allogeneic,
ex vivo-expanded cytotoxic T-lymphocytes (CTLs) specifically reactive to human adenovirus
(Ad), with potential immunomodulating and anti-adenoviral activities. Upon administration,
the allogeneic most closely HLA-matched Ad-specific CTLs may reconstitute Ad-specific
CTL responses in patients at risk of developing Ad infections either following allogeneic
stem cell transplantation or in Ad-infected immunocompromised hosts. The anti-adenoviral
CTLs are provided by a third party donor and not by the allogeneic stem cell transplant
donor.;
NCI Metathesaurus CUI : CL552245;
Origin ID : C150553;
UMLS CUI : C4725828;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
