Preferred Label : Ad5 [E1-, E2b-]-HER2/Neu Vaccine ETBX-021;
NCIt synonyms : Adenovirus Type 5 E1/E2b-deleted HER2/neu Vaccine ETBX-021; Ad5 [E1-, E2b-]-HER2/neu Vaccine;
NCIt related terms : ETBX-021;
NCIt definition : A cancer vaccine composed of a genetically engineered, replication-defective oncolytic
adenovirus serotype 5 (Ad5) vector, in which the E1, E2b and E3 genes are deleted,
that encodes a modified version of the tumor-associated antigen (TAA) human epidermal
growth factor receptor 2 (HER2/neu; ErbB-2; ERBB2), with potential antineoplastic
activity. Upon administration of Ad5 [E1-, E2b-]-HER2/neu ETBX-021, the vector expresses
HER2/neu and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against
tumor cells expressing the HER2/neu antigen. This results in the immune-mediated induction
of death in and inhibition of proliferation of HER2/neu-expressing tumor cells. HER2/neu,
a member of the epidermal growth factor receptor (EGFR) family of tyrosine kinases,
is overexpressed in various tumor cell types while expression is restricted and minimal
in certain normal healthy cells. It plays a key role in cancer cell proliferation
and survival. The gene deletions in Ad5 may circumvent pre-existing anti-adenovirus
immunity, allow HER2 gene insertion and expression and induce a strong immune response.;
UNII : S4MK9TOL0D;
CAS number : 2171509-20-7;
Molecule name : ETBX-021;
NCI Metathesaurus CUI : CL552279;
Origin ID : C150517;
UMLS CUI : C4725795;
Semantic type(s)
- concept_is_in_subset
