Preferred Label : Polymer-encapsulated Luteolin Nanoparticle;
NCIt synonyms : Nanoluteolin; Nano-luteolin; Nanoparticle-based Luteolin; 3',4',5,7-Tetrahydroxyflavone-encapsulated Polymer Nanoparticles;
NCIt definition : A nanoparticle formulation containing the poorly water-soluble naturally-occurring
flavonoid luteolin encapsulated within a water-soluble polymer, with potential anti-oxidant,
anti-inflammatory, apoptosis-inducing and chemopreventive activities. Upon administration
of the polymer-encapsulated luteolin nanoparticle, luteolin scavenges free radicals,
protects cells from reactive oxygen species (ROS)-induced damage and induces direct
tumor cell cycle arrest and apoptosis in tumor cells. This inhibits tumor cell proliferation
and suppresses metastasis. Compared to luteolin alone, encapsulation increases the
delivery of luteolin to the tumor cells by protecting the drug against clearance and
degradation, increases blood circulation time and enhances delivery into the tumor
through the leaky vasculature.;
NCI Metathesaurus CUI : CL552290;
Origin ID : C150508;
UMLS CUI : C4725788;
Semantic type(s)
- concept_is_in_subset
