HHV8-Positive Germinotropic Lymphoproliferative Disorder

Preferred Label : HHV8-Positive Germinotropic Lymphoproliferative Disorder;

NCIt synonyms : GLPD; KSHV/HHV8-Positive Germinotropic Lymphoproliferative Disorder; HHV8 GLPD; KSVH/HHV8 GLPD;

NCIt definition : A monotypic HHV8-positive lymphoproliferative disorder that usually occurs in HIV-negative individuals. It is characterized by the presence of HHV8-positive plasmablasts partially or completely replacing germinal centers. Coinfection with EBV is characteristic. In most cases, there is a favorable response to chemotherapy or radiation. (WHO 2017);

Neoplastic status : Undetermined;

NCI Metathesaurus CUI : CL552150;

Details

Origin ID

C150405;

UMLS CUI

C4725706;

Automatic exact mappings (from CISMeF team)
- Germinotropic lymphoproliferative disorder caused by Human herpesvirus 8 (disorder) [SNOMED CT concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Germinotropic lymphoproliferative disorder caused by Human herpesvirus 8 (disorder) [SNOMED CT concept]
- KSHV/HHV8-positive germinotropic lymphoproliferative disorder [MedDRA LLT]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Plasmablast [NCIt concept]
disease_has_associated_disease
- EBV Infection [NCIt concept]
- HHV8 Infection [NCIt concept]
disease_has_finding
- Epstein-Barr Virus Positive [NCIt concept]
disease_has_normal_cell_origin
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]

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