Preferred Label : ssRNA-based Immunomodulator CV8102;
NCIt synonyms : RNA-based Adjuvant CV8102;
NCIt related terms : CV-8102;
NCIt definition : A 547 nucleotide (nt), noncoding, uncapped single-stranded RNA (ssRNA) containing
several polyU-repeats complexed with a polymeric carrier formed by disulfide-crosslinked
cationic peptides, with potential immunostimulating activity. Upon intratumoral injection,
the ssRNA in CV8102 activates toll-like receptors (TLRs) and retinoic acid-inducible
gene I (RIG I; RIG-I; DDX58). This stimulates a T-helper type 1 cell (Th1) response,
the production of a variety of pro-inflammatory cytokines and chemokines, and activates
a systemic cytotoxic-T-lymphocyte (CTL)-mediated immune response against the tumor
cells when simultaneously exposed to tumor-associated antigens (TAAs). The cationic
carrier peptides protect the ssRNA from RNase degradation.;
UNII : ULM5THL8W5;
Drug name : RNAdjuvant;
Molecule name : CV 8102; CV-8102;
NCI Metathesaurus CUI : CL552154;
Origin ID : C150401;
UMLS CUI : C4725703;
Semantic type(s)
- concept_is_in_subset
