Preferred Label : Gallium Ga 68-NOTA-RM26;
NCIt synonyms : 68Ga-NOTA-RM26;
NCIt definition : A radioconjugate containing RM26, a synthetic bombesin analogue and antagonist of
the gastrin-releasing peptide receptor (GRPR), that is linked, through the macrocyclic
chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) to the radionuclide
gallium (Ga) 68, with potential use in diagnostic imaging using positron emission
tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68-NOTA-RM26,
the peptide moiety targets and binds to GRPR. Upon PET/CT, GRPR-expressing tumor cells
can then be visualized. GRPR, also called bombesin receptor subtype 2 (BB2), is a
G protein-coupled seven-transmembrane receptor belonging to the bombesin receptor
family. It is overexpressed in certain types of cancers.;
NCI Metathesaurus CUI : CL552158;
Origin ID : C150397;
UMLS CUI : C4725700;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
