Preferred Label : Fluorine F 18 Integrin Alpha v Beta 6-targeted Peptide;
NCIt synonyms : 18F-aVb6-Binding-Peptide; 18F-aVb6-BP; 18F-alphavbeta6-binding Peptide;
NCIt definition : A radiotracer composed of an integrin alphaVbeta6 (aVb6) binding peptide (BP) radiolabeled
with the radionuclide fluorine F 18, with potential integrin aVb6 imaging activity
using positron emission tomography (PET). Upon administration, the fluorine F 18 integrin
aVb6-targeted peptide selectively binds to integrin aVb6-positive cancer cells. During
PET, aVb6-expressing tumor cells can be visualized and the degree of tumor growth
can be determined. Integrin aVb6, a cell adhesion and signaling receptor, is upregulated
in certain cancer cell types and has been associated with increased proliferation,
migration and invasion of tumor cells.;
NCI Metathesaurus CUI : CL552159;
Origin ID : C150392;
UMLS CUI : C4524378;
Semantic type(s)
- concept_is_in_subset
