Preferred Label : Vandetanib-eluting Radiopaque Bead BTG-002814;
NCIt synonyms : Vandetanib-eluting Radiopaque Embolic Beads; VTB-loaded Beads; VERB; VERB BTG-002814;
NCIt definition : Radiopaque drug-eluting beads (DEBs) that are loaded with vandetanib, a dual inhibitor
of both vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor
receptor (EGFR), with potential antineoplastic, anti-angiogenic and imaging activities.
Upon intra-arterial hepatic artery administration of vandetanib (VTB)-eluting Radiopaque
beads (VERBs) BTG-002814, the DEBs occlude the tumor blood vessels and deprive tumor
cells of oxygen and nutrients, thereby causing hepatic arterial embolization and direct
tumor cell death. The VERBs release vandetanib from the beads in a sustained manner.
Vandetanib selectively inhibits the tyrosine kinase activity of both VEGFR and EGFR,
thereby blocking both VEGF/VEGFR- and EGF/EGFR-stimulated signaling and inhibiting
cell proliferation, migration and angiogenesis in VEGFR/EGFR-expressing hepatic tumor
cells. The DEBs, controlled release microspherical devices, cause low systemic exposure
and prevent systemic toxicity of vandetanib. DEBs also deliver high concentrations
of vandetanib in the tumor for a controlled and extended period of time. Use of radiopaque
DEBs allows for visualization of both the bead location and the degree of embolization
upon imaging.;
Molecule name : BTG-002814;
NCI Metathesaurus CUI : CL552167;
Origin ID : C150384;
UMLS CUI : C4723692;
Semantic type(s)
- concept_is_in_subset
