Preferred Label : Imaging Agent QRH-882260 Heptapeptide;
NCIt synonyms : QRH-882260 Cy-5-labeled Heptapeptide; Fluorescently-labeled Peptide QRH-882260; Gln-Arg-His-Lys-Pro-Arg-Glu-Gly-Gly-Gly-Ser-Lys(Cy5)-NH2; QRHKPRE-GGGSK-(Cy5)-NH2; Fluorescence Peptide QRH-882260;
NCIt related terms : QRH-882260;
NCIt definition : An orally bioavailable fluorescent imaging agent composed of the near-infrared (NIR)
fluorophore cyanine 5 (Cy5) linked to a seven-amino acid long peptide that specifically
binds to the tumor-associated antigen (TAA) epithelial growth factor receptor (epidermal
growth factor receptor; EGFR), that can potentially be used for the imaging of EGFR-expressing
tumor cells. Upon oral administration of the fluorescent imaging agent QRH-882260
heptapeptide, the peptide moiety selectively binds to EGFR expressed on tumor cells
in the gastrointestinal (GI) tract. Upon fluorescence imaging, EGFR-expressing tumor
cells can be visualized. EGFR, a member of the epidermal growth factor receptor family,
is overexpressed on the surfaces of various tumors cells.;
UNII : HL2W44VNI8;
Molecule name : QRH-882260;
NCI Metathesaurus CUI : CL552178;
Origin ID : C150373;
UMLS CUI : C4725687;
Semantic type(s)
- concept_is_in_subset
