Preferred Label : Expanded Cord Blood Stem Cells Mixed with Engineered Human Endothelial Cells AB-110;
NCIt synonyms : AB-110 Cell Product; Genetically-modified Endothelial Cells Plus Expanded Cord Blood Hematopoietic Stem
Cells AB-110; Cord Blood-derived HPCs Co-cultured and Expanded with E-CEL UVEC Cells AB-110; CD34 Cord-Blood Derived Hematopoietic Stem Cells Co-Cultured and Co-Infused with
Genetically Modified Endothelial Cells AB-110; CD34-positive Enriched HPCs Mixed with Engineered Human ECs AB-110;
NCIt definition : A population of ex vivo expanded, CD34-positive-enriched hematopoietic progenitor
cells (HPCs), which are derived from allogeneic human umbilical cord blood (UCB),
and are co-cultured and expanded with a proprietary preparation of human endothelial
cells (ECs), which are genetically modified with an adenovirus (Ad) vector that includes
the Ad E4 region that encodes the ORF1 (E4ORF1) gene, that can be used for transplantation.
Upon transplantation of the expanded cord blood stem cells mixed with engineered human
ECs AB-110, the UCB-derived cells can differentiate into a variety of cell types and
promote blood cell recovery. Compared to bone marrow transplants, these HPCs demonstrate
a decreased risk of causing graft-versus-host disease (GvHD), increase survival and
enhance the potential for transplant and engraftment in any given patient as there
is no need for a matched donor. Compared to HPCs alone, inclusion of the ECs increases
blood stem cell count, enhances engraftment potential and increases the chances for
blood cell recovery, thereby further increasing the potential for a successful cord
blood transplantation. Insertion of the Ad E4ORF1 gene enhances survival and replication
of the ECs ex vivo, preserves the ECs' vascular functions and improves the ability
of the ECs to secrete angiocrines, which promotes stem cell proliferation and increases
engraftment.;
Molecule name : AB-110; AB 110;
NCI Metathesaurus CUI : CL551914;
Origin ID : C150135;
UMLS CUI : C4727680;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
