Preferred Label : Ceftolozane;
NCIt synonyms : (6R,7R)-3-((5-Amino-4-(((2-aminoethyl)carbamoyl)amino)-1-methyl-1H-pyrazol-2-ium-2-
yl)methyl)-7-(((2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-((1-carboxy-1- methylethoxy)imino)acetyl)amino)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-
Carboxylate; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 3-((4-((((2- Aminoethyl)amino)carbonyl)amino)-2,3-dihydro-3-imino-2-methyl-1H-pyrazol-1-
yl)methyl)-7-(((2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-((1-carboxy-1- methylethoxy)imino)acetyl)amino)-8-oxo-,
(6R,7R)-;
NCIt definition : A semi-synthetic, broad-spectrum, fifth-generation cephalosporin antibiotic with bactericidal
activity against certain Gram-negative and Gram-positive bacteria. Upon administration,
ceftolozane binds to and inactivates penicillin-binding proteins (PBPs) located on
the inner membrane of the bacterial cell wall. This interferes with the final transpeptidation
step required to form peptidoglycan chain cross-links, which are a key component of
and provide strength and rigidity to the bacterial cell wall. This inhibits bacterial
cell wall synthesis and reduces cell wall stability, which weakens the bacterial cell
wall and causes bacterial cell lysis.;
UNII : 37A4IES95Q;
InChIKey : JHFNIHVVXRKLEF-DCZLAGFPSA-N;
CAS number : 689293-68-3;
Molecule name : CXA-101;
NCI Metathesaurus CUI : CL551786;
Origin ID : C150024;
UMLS CUI : C3852726;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
