NCIt definition : A recombinant therapeutic agent chemically identical to endogenous human GM-CSF except
a leucine substitution in position 23. Binding to specific cell surface receptors,
sargramostim modulates the proliferation and differentiation of a variety of hematopoietic
progenitor cells with some specificity towards stimulation of leukocyte production
and may reverse treatment-induced neutropenias. This agent also promotes antigen presentation,
up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated
lymphokine-activated killer cell function; it may also augment host antitumoral immunity.;
Alternative definition : NCI-GLOSS: A substance that helps make more white blood cells, especially granulocytes,
macrophages, and cells that become platelets. It is a cytokine that is a type of hematopoietic
(blood-forming) agent.;
UNII : 5TAA004E22;
CAS number : 123774-72-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 123774-72-1
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