" /> Sargramostim - CISMeF





Preferred Label : Sargramostim;

NCIt synonyms : Sagramostim; rhu GM-CFS; 23-L-Leucinecolony-Stimulating Factor 2; Sargramostatin;

NCIt definition : A recombinant therapeutic agent chemically identical to endogenous human GM-CSF except a leucine substitution in position 23. Binding to specific cell surface receptors, sargramostim modulates the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production and may reverse treatment-induced neutropenias. This agent also promotes antigen presentation, up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function; it may also augment host antitumoral immunity.;

Alternative definition : NCI-GLOSS: A substance that helps make more white blood cells, especially granulocytes, macrophages, and cells that become platelets. It is a cytokine that is a type of hematopoietic (blood-forming) agent.;

UNII : 5TAA004E22;

CAS number : 123774-72-1;

Drug name : Prokine; Leukine;

Molecule name : DRG-0012;

Codes from synonyms : CDR0000045304; 459;

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11/05/2025


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